Strategies for Constructing Tissue-Engineered Fat for Soft Tissue Regeneration
10.1007/s13770-023-00607-z
- Author:
Jing ZHAO
1
;
Feng LU
;
Ziqing DONG
Author Information
1. Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou 510515, Guangdong, China
- Publication Type:REVIEW ARTICLE
- From:
Tissue Engineering and Regenerative Medicine
2024;21(3):395-408
- CountryRepublic of Korea
- Language:EN
-
Abstract:
BACKGROUND:Repairing soft tissue defects caused by inflammation, tumors, and trauma remains a major challenge for surgeons. Adipose tissue engineering (ATE) provides a promising way to solve this problem.
METHODS:This review summarizes the current ATE strategies for soft tissue reconstruction, and introduces potential construction methods for ATE.
RESULTS:Scaffold-based and scaffold-free strategies are the two main approaches in ATE. Although several of these methods have been effective clinically, both scaffold-based and scaffold-free strategies have limitations. The third strategy is a synergistic tissue engineering strategy and combines the advantages of scaffold-based and scaffold-free strategies.
CONCLUSION:Personalized construction, stable survival of reconstructed tissues and functional recovery of organs are future goals of building tissue-engineered fat for ATE.
