Severe Liver Dysfunction after Donor Lymphocyte Infusion for Relapsed Multiple Myeloma
- Author:
Tae-Hoon NO
1
;
Nae-Yun HEO
;
Seung Ha PARK
;
Joon Hyuk CHOI
;
Junghwan LEE
;
Sung Nam LIM
;
Seon Yang PARK
Author Information
- Publication Type:CASE REPORT
- From:The Korean Journal of Gastroenterology 2024;83(3):123-126
- CountryRepublic of Korea
- Language:EN
- Abstract: Donor lymphocyte infusion (DLI) is performed to augment an anti-tumor immune response or ensure donor stem cells remain engrafted following allogeneic stem cell transplantation but may induce graft-versus-host disease (GVHD) involving skin, intestine, and liver. Although hepatic involvement of GVHD can manifest as mild to severe hepatitis, few reports have mentioned acute severe liver dysfunction with encephalopathy. We experienced a case of acute severe liver dysfunction with semicoma after DLI in a patient with relapsed multiple myeloma following allogeneic stem cell transplantation, in whom chronic viral hepatitis B had been suppressed by antiviral treatment. The patient recovered after high-dose glucocorticoid administration based on an assessment of hepatic GVHD.Clinicians should be aware of the possibility of this catastrophic hepatic complication after DLI in hematologic disorders.
