Benzoquinone Derivatives with Neuroprotective Activities from Lysimachia vulgaris L.
- Author:
Chan-Woong PARK
1
;
Jeonghoon LEE
;
Pisey PEL
;
Seung-Eun LEE
;
Young-Won CHIN
Author Information
- From:Natural Product Sciences 2024;30(1):1-7
- CountryRepublic of Korea
- Language:English
- Abstract: The ethyl acetate-soluble fraction of Lysimachia vulgaris , which was found to suppress β-amyloid production in Aβ-treated PC12 cells, was purified using various column chromatographies, resulting in the isolation of four known compounds, 2,4,6-triphenylhex-1-ene (1), pinoresinol (2), monomethyl embelin (3), and 2-hydroxy-5-methoxy-3-tridecyclohexa-2,5-diene-1,4-dione (4). The isolated compounds 3 and 4 downregulated P-tau production in Aβ-treated SH-SY5Y cells and demonstrated the inhibitory activities against NO production in lipopolysaccharide (LPS)-treated BV2 cells.
