Indole Derivatives and a Diketopiperazine from Chromobacterium violaceum
- Author:
Hye Ryeong KIM
1
;
Gyu Sung LEE
;
InWha PARK
;
Chung Sub KIM
Author Information
- From:Natural Product Sciences 2024;30(2):130-134
- CountryRepublic of Korea
- Language:English
- Abstract: Three indole derivatives (1–3) and a diketopiperazine (4) were isolated from the ethyl acetate extract of Chromobacterium violaceum. Their structures were elucidated based on the analysis of NMR and HR-MS data and by comparing those in the previous literature. The antibacterial activities of the isolated compounds were evaluated against Gram-positive bacteria, including human pathogenic methicillin-resistant Staphylococcus aureus (MRSA), Lacticaseibacillus paracasei subsp. paracasei, and Brevibacterium epidermidis. Compound 1 exhibited moderate antibacterial activity against all the three strains with MIC values ranging from 8.58 to 34.3 μg/mL.
