Isolation and Identification of Antifungal Metabolites from Juncus torreyi
- Author:
Seong Ho PARK
1
;
Ji Won KANG
;
Ga Hyeon PARK
;
So-Jung JO
;
Kyung-Won MIN
;
Kyu Song LEE
;
Hyun Bong PARK
Author Information
- From:Natural Product Sciences 2024;30(2):161-166
- CountryRepublic of Korea
- Language:EN
- Abstract: Plants belonging to the genus Juncus are widely distributed across North America, which are known to make a diverse array of bioactive natural products. In 2022, Juncus torreyi, a species of Juncus, was firstly found in Korea. Morphological and ecological characteristics of the species have been previously investigated;however, bioactive chemical potentials still remain to be explored. In the present work, we focused on the isolation and characterization of metabolites that harbor growth inhibitory activity against a fungal indicator, Candida albicans. Using activity-guided discovery method, we subsequently isolated and purified three metabolites from the most active methylene chloride-soluble fraction. Through NMR and high-resolution ESIOrbitrap-MS data analysis, the metabolites were structurally determined to be juncatrin B (1), ensifolin I (2), and juncusol (3). Metabolites 1–3 were evaluated for their C. albicans growth inhibitory activity and revealed inhibition with an IC 50 value of 74.3, 31.5, and 64.6 μg/mL, respectively.
