Naringin from sweet orange peel improves testicular function in high fat diet‑induced diabetic rats by modulating xanthine oxidase/ uric acid signaling and maintaining redox balance
10.1186/s42826-024-00188-5
- Author:
Kazeem Bidemi OKESINA
1
;
Adeyemi Fatai ODETAYO
;
Wale Johnson ADEYEMI
;
Ayodeji Johnson AJIBARE
;
Akeem Ayodeji OKESINA
;
Luqman Aribidesi OLAYAKI
Author Information
1. Department of Medical Physiology, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.
- Publication Type:RESEARCH
- From:Laboratory Animal Research
2024;40(1):64-73
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Type 2 diabetes mellitus (T2DM) is a metabolic disorder affecting many organs, including the testis. Naringin from orange peel extract (OPE) is a flavanone with fertility-enhancing properties. Hence, this study was designed to establish the effect of naringin on T2DM-induced testicular dysfunction. Thirty male (30) Wistar rats were randomized into five groups control, diabetes, diabetes + naringin, diabetes + OPE, and diabetes + metformin. The administrations were via the oral route and lasted for 28 days.
Results:Naringin ameliorated T2DM-induced increase in FBS and decrease in serum insulin. It also abrogated T2DMinduced decrease in sperm quality, gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol, prolactin, catalase, superoxide dismutase, and total antioxidant capacity. Furthermore, naringin prevented a T2DM-induced increase in malonaldehyde, tumor necrosis factor-alpha, C-reactive protein, xanthine oxidase (XO), and uric acid (UA), it was accompanied by the restoration of normal testicular histoarchitecture.
Conclusions:Naringin prevented T2DM-induced testicular dysfunction by modulating XO/UA and restoring redox balance. Also, while the animals treated with OPE exhibited better ameliorative effects than their counterparts treated with naringin, the findings from this study showed that naringin would be a promising supplement for treating T2DM-induced male infertility.
