Morin ameliorates myocardial injury in diabetic rats via modulation of inflammatory pathways
10.1186/s42826-024-00190-x
- Author:
Vipin Kumar VERMA
1
;
Salma MALIK
;
Ekta MUTNEJA
;
Anil Kumar SAHU
;
Vaishali PRAJAPATI
;
Prashant MISHRA
;
Jagriti BHATIA
;
Dharamveer Singh ARYA
Author Information
1. Cardiovascular Research Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India
- Publication Type:RESEARCH
- From:Laboratory Animal Research
2024;40(1):51-63
- CountryRepublic of Korea
- Language:EN
-
Abstract:
Background:High blood glucose levels in diabetes lead to vascular inflammation which accelerates atherosclerosis. Herein, Morin was orally administered in male Wistar rats, at the dose of 40 mg/kg for 28 days, and on the 27th and 28th day, ISO was administered to designate groups at the dose of 85 mg/kg s.c., to induce myocardial infarction.
Results:Free radical generation, including ROS, in diabetes following ISO administration, leads to the activation of both intrinsic and extrinsic pathways of apoptosis. Morin significantly (p ≤ 0.05) reduced oxidative stress (GSH, MDA, SOD), cardiac injury markers (CK-MB, LDH), inflammation (TNF, IL-6), and apoptosis (Bax, BCl 2 , Caspase-3). In addition, it also reduced insulin and blood glucose levels. Akt/eNOS, Nrf2/HO-1, MAPK signaling pathways, and Insulin signal transduction pathways were positively modulated by morin pre-treatment.
Conclusions:Morin attenuated oxidative stress and inflammation and also modified the activity of various molecular pathways to mitigate cardiomyocyte damage during ISO-induced MI in diabetic rats.
