The memory ameliorating effects of novel N‑benzyl pyridine‑2‑one derivatives on scopolamine‑induced cognitive deficits in mice
10.1186/s42826-023-00187-y
- Author:
Swati PANT
1
;
Mohan GUPTA
;
Tulika ANTHWAL
;
Monika CHAUHAN
;
Sumitra NAIN
Author Information
1. Department of Pharmacy, Banasthali Vidyapith, Banasthali, Tonk, Rajasthan, India
- Publication Type:RESEARCH
- From:Laboratory Animal Research
2024;40(1):104-114
- CountryRepublic of Korea
- Language:EN
-
Abstract:
Background:Alzheimer’s disease (AD), the most common form of progressive dementia in the elderly, is a chronic neurological disorder that decreases cognitive ability. Although the underlying cause of AD is yet unknown, oxidative stress and brain acetylcholine shortage are the key pathogenic causes.
Results:The current study shows that these derivatives have the potential to improve memory in mice by inhibiting scopolamine-induced acetylcholinesterase activity, oxidative and nitrosative stress, and improving locomotor activity and muscle grip strength in the rota rod test. When compared to the illness control, the memory-enhancing potential of novel N-benzyl pyridine-2-one derivatives was highly significant (P < 0.0001).
Conclusions:The observed memory ameliorating effect of novel N-benzyl pyridine-2-one makes them as a a good choice for treatment of individuals with cognitive impairment
