Clinical, Dermoscopic, and Histological Characteristics of Laugier-Hunziker Syndrome
- Author:
Jisang YUN
1
;
Yeona KIM
;
Sang-Hyeon WON
;
Jungsoo LEE
;
Hoonsoo KIM
;
Hyun-Chang KO
;
Byungsoo KIM
;
Moon-Bum KIM
;
Kihyuk SHIN
Author Information
1. Department of Dermatology, Pusan National University School of Medicine , Busan, Korea
- Publication Type:Original Article
- From:Korean Journal of Dermatology
2024;62(1):1-8
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Laugier-Hunziker syndrome (LHS) is a rare, benign, acquired disorder that is usually characterized by hyperpigmentation of the oral cavity and lips, along with longitudinal melanonychia. Till date, its characteristics have not been investigated in a large number of patients in a single-center study.
Objective:This study aimed to investigate the clinical, dermoscopic, and histological characteristics of LHS.
Methods:We retrospectively reviewed the medical records, biopsy specimens, and clinical and dermoscopic photographs of 21 patients diagnosed with LHS at Pusan National University Hospital (Busan and Yangsan) over a period of 15 years (2008∼2022).
Results:Among the 21 patients, 20 patients (95.2%) were female and one patient (4.8%) was male, and the mean age was 56.0 years (range: 18∼75 years). The lower lip (95.2%) was the most frequently affected oral mucosa, followed by the upper lip (81.0%), buccal mucosa (66.7%), tongue (57.1%), gingiva (42.9%), and palate (14.3%). The nails were the most commonly affected extraoral site, and in our study, eight of 21 patients (38.1%) presented with periungual lesions. Based on the dermoscopic findings, a globular pattern was the most common. Histologically, the lesions showed epithelial acanthosis and increased basal keratinocyte melanin without an increase in the number of melanocytes.
Conclusion:This is the first study to investigate the clinical, dermoscopic, and histological characteristics of patients with LHS. The results of this study could be helpful in understanding LHS.
