Symmetric dimethylarginine correlates with the urea, creatinine, potassium, and clinical scores in feline urethral obstructions
- Author:
Jéssica Cavalcante da NÓBREGA
1
;
Heloíse Rangel DINALLO
;
Silvano Salgueiro GERALDES
;
Maria Gabriela Picelli de AZEVEDO
;
Reiner Silveira de MORAES
;
Suellen Rodrigues MAIA
;
Fabiana Ferreira de SOUZA
;
Alessandra MELCHERT
;
Henry David Mogollón GARCÍA
;
Raphael Lúcio Andreatti FILHO
;
Adriano Sakai OKAMOTO
;
Priscylla Tatiana Chalfun Guimarães OKAMOTO
Author Information
- Publication Type:Original Article
- From:Journal of Veterinary Science 2024;25(2):e27-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:A urethral obstruction (UO) is an emergency commonly observed in male cats, which can result in significant clinical and laboratory alterations, leading to complications and death.
Objectives:This study aimed to correlate symmetric dimethylarginine (SDMA) with the urea, creatinine, potassium, and bicarbonate levels in cats with UO. In addition, the correlation between clinical score and time of obstruction was evaluated.
Methods:Thirty male cats were selected and allocated into a control group (CG, n = 13) and an obstruction group (OG, n = 17). The laboratory analyses were conducted before treatment (M0) and at different times after treatment (12 h [M12], 24 h [M24], and 48 h [M48]).Correlations were established between SDMA and creatinine, urea, bicarbonate, potassium, time of obstruction, and the clinical score.
Results:A strong correlation (r > 0.6) was observed between SDMA and creatinine, urea, and potassium in the OG. Furthermore, there was substantial agreement (kappa value) between SDMA and creatinine at M24. A higher clinical score was associated with a longer time of obstruction. In the OG, at M48, the SDMA and creatinine levels were 50% and 41.2% higher, respectively.
Conclusions:A correlation was observed between SDMA and creatinine in obstructed cats, and significant agreement between these values was observed 24 h after the unblocking treatment. A correlation among SDMA, urea, and potassium was observed. Approximately 9% more cats continued to have elevated SDMA levels after 48 h of treatment compared to creatinine. This suggests a slightly lower sensitivity of the latter biomarker but does not exclude the possibility of congruent and normalized values after a longer evaluation period.
