Association between the platelet-to-hemoglobin ratio and survival-to-discharge in comatose patients with out-of-hospital cardiac arrest with an initial shockable rhythm: a retrospective cohort study
- Author:
Yeon Ah PARK
1
;
Eun Jung PARK
;
Young Gi MIN
;
Min Ji PARK
;
Sung Eun LEE
Author Information
1. Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea
- Publication Type:Original Article
- From:Journal of the Korean Society of Emergency Medicine
2024;35(3):203-211
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:This study examined whether the platelet-to-hemoglobin ratio (PHR) is associated with survival-to-discharge in comatose patients with out-of-hospital cardiac arrest (OHCA) with an initial shockable rhythm.
Methods:This retrospective cohort study included adult comatose patients after OHCA with an initial shockable rhythm between January 2015 and December 2021. This study analyzed the relationship between the basic characteristics and initial laboratory findings, including PHR, and survival-to-discharge. The primary outcome was defined as survival-to-discharge, and the secondary outcome was a good neurological outcome (cerebral performance category 1-2) at the time of discharge.
Results:One hundred and ten patients were included in this study, of whom 86 (78%) survived to discharge. The survival-to-discharge group had a significantly higher initial platelet count (238.5±78.1 vs. 158.4±47.2 ×103/μL; P<0.05) and PHR (1.7±0.5 vs. 1.2±0.3; P<0.05) than the non-survival-to-discharge group. Even after adjusting for multiple confounding factors, platelet count and PHR remained associated with survival-to-discharge (adjusted odds ratio [aOR] of 1.02, 95% confidence interval [CI] 1.01-1.03, P=0.009 and aOR of 9.99, 95% CI 1.96-50.87, P=0.006, respectively). The platelet count and PHR feasibly predicted the survival-to-discharge (area under the receiver operating characteristic curves are 0.831 and 0.806, respectively).
Conclusion:In this cohort study, a high platelet count and PHR could be associated with the survival-to-discharge in patients with OHCA with an initial shockable rhythm.
