SOCS1 and SOCS3 are expressed in mononuclear cells in human cytomegalovirus viremia after allogeneic hematopoietic stem cell transplantation.
- Author:
Seung Hwan SHIN
1
;
Ji Yoon LEE
;
Tae Hyang LEE
;
So Hye PARK
;
Seung Ah YAHNG
;
Jae Ho YOON
;
Sung Eun LEE
;
Byung Sik CHO
;
Dong Gun LEE
;
Yoo Jin KIM
;
Seok LEE
;
Chang Ki MIN
;
Seok Goo CHO
;
Dong Wook KIM
;
Jong Wook LEE
;
Woo Sung MIN
;
Chong Won PARK
;
Hee Je KIM
Author Information
- Publication Type:Original Article
- Keywords: Suppressor of cytokine signaling (SOCS) 1 and 3; Cytomegalovirus (CMV) viremia; Quantitative real-time PCR; Allogeneic HSCT; GVHD
- MeSH: Cytomegalovirus*; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation*; Humans; Tissue Donors; Viremia*
- From:Blood Research 2015;50(1):40-45
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: The expression of the SOCS genes in cytomegalovirus (CMV) viremia after hematopoietic stem cell transplantation (HSCT) remains largely unexplored. METHODS: Using quantitative RT-PCR of mononuclear cells, we conducted pairwise comparison of SOCS1 and SOCS3 expression levels among a healthy donor group (N=55), a pre-HSCT group (N=17), and the recipient subgroup (N=107), which were divided according to the occurrence of CMV viremia and acute graft-versus-host disease (aGVHD). RESULTS: Compared to that in the healthy donor group, SOCS1 expression was higher in the CMV+ subgroup, especially in the CMV+GVHD- group, but decreased in the other subgroups. When compared to the expression in the pre-HSCT group, SOCS1 expression was significantly higher in the CMV+ subgroup, especially in the CMV+GVHD+ subgroup. Meanwhile, compared to that in the healthy donor group, SOCS3 expression was significantly lower in all other groups. The CMV-GVHD- subgroup showed significantly lower SOCS3 expression compared to the CMV+ subgroup, the CMV+GVHD+ subgroup, and the CMV+GVHD- subgroup. CONCLUSION: We report differential expression of SOCS genes according to CMV viremia with acute GVHD occurrence after HSCT, suggesting that regulation of SOCS expression is associated with CMV viremia.
