Effects of the interaction between seaweed consumption and the polygenic risk score on inflammation in Korean adults
10.4163/jnh.2024.57.2.211
- Author:
Gayeon HONG
1
;
Dayeon SHIN
Author Information
1. Department of Food and Nutrition, Inha University, Incheon 22212, Republic of Korea
- Publication Type:Research Article
- From:Journal of Nutrition and Health
2024;57(2):211-227
- CountryRepublic of Korea
- Language:EN
-
Abstract:
Methods:Information on seaweed consumption was collected using a food frequency questionnaire, which included laver, kelp, and sea mustard among the items consumed. A total of 31 hs-CRP-related single nucleotide polymorphisms (SNPs) were selected using genomewide association studies and clumping analysis, and the individual PRS were calculated by weighting the effect size of each allele in the selected SNPs of 39,369 middle-aged (≥40 years) Koreans using the Korean Genome and Epidemiology Study (KoGES)-Health Examinees (HEXA) cohort data. To investigate the interaction between seaweed intake and the PRS on hs-CRP levels >1 mg/L, hazard ratios (HRs) and 95% confidence intervals (CIs) were assessed using multivariable Cox proportional hazards models.
Results:During a mean follow-up period of 4.8 years, we recorded 436 patients with elevated hs-CRP levels. Women in the highest tertile of the PRS with the lowest quartile of seaweed intake had an increased incidence of elevated hs-CRP levels compared with women in the lowest tertile of the PRS with the lowest seaweed intake quartile (HR 2.34, 95% CI 1.23–4.45). No significant association was observed among the men.
Conclusion:In conclusion, we identified a new interaction between the PRS, seaweed intake, and inflammation in Korean women, and this study suggests that the interaction between the identification of genetic predisposition and dietary seaweed intake may have an impact on determining the risk of developing hyperinflammation in the future.
