The Effect of Omega-3 Supplementation on Heart Failure Outcome:A Meta-Analysis of Randomized Clinical Trial
10.12997/jla.2024.13.2.89
- Author:
Bambang DWIPUTRA
1
;
Ade Meidian AMBARI
;
Dwita Rian DESANDRI
;
Budhi Setianto PURWOWIYOTO
;
Basuni RADI
;
Bashar Adi Wahyu PANDHITA
;
Serlie FATRIN
;
Anwar SANTOSO
Author Information
1. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, DKI Jakarta, Indonesia
- Publication Type:Review
- From:Journal of Lipid and Atherosclerosis
2024;13(2):89-96
- CountryRepublic of Korea
- Language:English
-
Abstract:
The effect of omega-3 supplementation on cardiovascular (CV) disease has been widely studied in several large clinical trials. However, the evidence of the effect of omega-3 supplementation in patients with heart failure (HF) remains controversial. This meta-analysis investigated the effects of omega-3 supplementation on patients with HF. We conducted a literature search on MEDLINE, Embase, and Cochrane databases for clinical trials and preprints of relevant articles. Following a literature search and critical appraisal, 5 studies were included in the meta-analysis. The pooling of the result of the studies shows that there were no significant association between omega-3 supplementation and CV mortality (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.84–1.05, p=0.16) nor hospitalization due to HF (OR, 0.94; 95% CI, 0.88–1.02; p=0.13). Our systematic review and meta-analysis showed that omega-3 supplementation has no beneficial effect in patients with HF.
