Is Vitamin D an Independent Risk Factor of Nonalcoholic Fatty Liver Disease?: a Cross-Sectional Study of the Healthy Population.
10.3346/jkms.2017.32.1.95
- Author:
Danbee PARK
1
;
Hyuktae KWON
;
Seung Won OH
;
Hee Kyung JOH
;
Seung Sik HWANG
;
Jin Ho PARK
;
Jae Moon YUN
;
Hyejin LEE
;
Goh Eun CHUNG
;
Sangjoon ZE
;
Jae Hong PARK
;
Yeseul BAE
;
Arang LEE
Author Information
1. Department of Family Medicine, Seoul National University Hospital, Seoul, Korea. hyuktae@gmail.com
- Publication Type:Original Article
- Keywords:
Vitamin D;
Non-Alcoholic Fatty Liver Disease;
Metabolic Syndrome X;
Intra-Abdominal Fat;
Sex
- MeSH:
Adult;
Cross-Sectional Studies;
Female;
Hematologic Tests;
Humans;
Intra-Abdominal Fat;
Logistic Models;
Male;
Mass Screening;
Metabolic Syndrome X;
Non-alcoholic Fatty Liver Disease*;
Odds Ratio;
Risk Factors*;
Sex Characteristics;
Ultrasonography;
Vitamin D Deficiency;
Vitamin D*;
Vitamins*
- From:Journal of Korean Medical Science
2017;32(1):95-101
- CountryRepublic of Korea
- Language:English
-
Abstract:
The association between vitamin D levels and nonalcoholic fatty liver disease (NAFLD) has been recognized. However, few studies showed independent associations between vitamin D deficiency and NAFLD after a sex-related adjustment for metabolic factors. We aimed to study whether vitamin D deficiency is an independent risk factor of NAFLD even after controlling for metabolic syndrome and visceral fat in both sexes. In this cross-sectional study, 7,514 Korean adults (5,278 men, 2,236 women) participated in a health check-up program. They underwent blood tests, abdominal computed tomography (CT) of the visceral fat area, and ultrasonography for NAFLD screening. Multiple logistic regression analysis was used to investigate the association of vitamin D deficiency with NAFLD according to the sex differences. Vitamin D deficiency is associated with NAFLD. The adjusted odds ratio (aOR) for NAFLD increased sequentially with decreasing vitamin D level, even after adjusting for metabolic syndrome and visceral fat. The subjects in the vitamin D sufficiency group (20–30 ng/mL) had an aOR for NAFLD of 1.18 (95% CI, 1.00–1.39), whereas the deficiency group (< 20 ng/mL) had an aOR of 1.29 (95% CI, 1.10–1.52). However, we have detected a significant sex-related interaction when analyzing the results. A significant relationship between vitamin D deficiency and NAFLD was found in men (aOR, 1.33; 95% CI, 1.11–1.60) but not in women.
