White Matter Microstructure Alterations in Schizophrenia With Auditory Verbal Hallucination: Diffusion Tensor Imaging Study
10.4306/jknpa.2024.63.1.76
- Author:
MyungJe SUNG
1
;
Jina JUNG
;
KiWon SONG
;
Takjong JUNG
;
Hae Kook LEE
Author Information
1. Institute Forensic Psychiatry Research, National Forensic Hospital, Gongju, Korea
- Publication Type:ORIGINAL ARTICLE
- From:Journal of Korean Neuropsychiatric Association
2024;63(1):76-82
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objectives:To compare the white matter microstructure alterations in schizophrenia with auditory verbal hallucinations (AVHs) with normal persons using diffusion tensor imaging.
Methods:Thirty-five schizophrenia patients with AVHs and 33 normal control persons were recruited from the National Forensic Hospital in Korea. The fractional anisotropy (FA) values of arcuate fasciculus (AF), Broca’s area, and Wernicke’s area were estimated from the diffusion tensor imaging data of each subject using the Johns Hopkins University-white matter tractography atlas to determine the difference in white matter integrity between schizophrenia patients with AVH and normal persons.
Results:Compared to the normal control group, the FA values of AF (t=4.349, p<0.001) were higher in the normal control group. On the other hand, there were no significant differences in Broca’s area and Wernicke’s area.
Conclusion:Microstructural changes of AF are certainly involved in schizophrenia patients with AVHs.
