Lower-Body Fractures and the Risk of Dementia:A Nationwide Population-Based Study
- Author:
Jung-Kyeom KIM
1
;
Sang-Won PARK
;
Suk-Hee LEE
;
Payam Hosseinzadeh KASANI
;
Gi Hwan BYEON
;
Yeshin KIM
;
Jae-Won JANG
;
Seo-Young LEE
Author Information
- Publication Type:ORIGINAL ARTICLE
- From:Journal of Clinical Neurology 2024;20(2):208-213
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:and Purpose The association between physical activity and dementia has been shown in various observational studies. We aimed to determine the risk of dementia in the elderly with lower-body fractures.
Methods:We reconstructed a population-based matched cohort from the National Health Insurance Service—Senior Cohort data set that covers 511,953 recipients of medical insurance in South Korea.
Results:Overall 53,776 subjects with lower-body fractures were identified during 2006–2012, and triplicate control groups were matched randomly by sex, age, and years from the index date for each subject with a fracture. There were 3,573 subjects (6.6%) with and 7,987 subjects (4.9%) without lower-body fractures who developed dementia from 2008 up to 2015. Lowerbody fractures were independently associated with a subsequent dementia diagnosis with a higher adjusted hazard ratio (aHR) (1.55, 95% confidence interval [CI]=1.49–1.62) compared with upper-body fractures (aHR=1.19, 95% CI=1.14–1.23).
Conclusions:These results support the protective role of physical activity against dementia and highlight the importance of promoting fracture prevention in the elderly.
