Guidelines for Manufacturing and Application of Organoids: Skin
- Author:
Seunghee LEE
1
;
Yeri Alice RIM
;
Juryun KIM
;
Su Hyon LEE
;
Hye Jung PARK
;
Hyounwoo KIM
;
Sun-Ju AHN
;
Ji Hyeon JU
Author Information
- Publication Type:SPECIAL REPORT
- From:International Journal of Stem Cells 2024;17(2):182-193
- CountryRepublic of Korea
- Language:EN
- Abstract: To address the limitations of animal testing, scientific research is increasingly focused on developing alternative testing methods. These alternative tests utilize cells or tissues derived from animals or humans for in vitro testing, as well as artificial tissues and organoids. In western countries, animal testing for cosmetics has been banned, leading to the adoption of artificial skin for toxicity evaluation, such as skin corrosion and irritation assessments. Standard guidelines for skin organoid technology becomes necessary to ensure consistent data and evaluation in replacing animal testing with in vitro methods. These guidelines encompass aspects such as cell sourcing, culture techniques, quality requirements and assessment, storage and preservation, and organoid-based assays.
