Innate Type-2 Cytokines: From ImmuneRegulation to Therapeutic Targets
- Author:
Hye Young KIM
1
;
Dongjin JEONG
;
Ji Hyung KIM
;
Doo Hyun CHUNG
Author Information
- Publication Type:Review Article
- From:Immune Network 2024;24(1):e6-
- CountryRepublic of Korea
- Language:EN
- Abstract: The intricate role of innate type-2 cytokines in immune responses is increasingly acknowledged for its dual nature, encompassing both protective and pathogenic dimensions.Ranging from defense against parasitic infections to contributing to inflammatory diseases like asthma, fibrosis, and obesity, these cytokines intricately engage with various innate immune cells. This review meticulously explores the cellular origins of innate type-2 cytokines and their intricate interactions, shedding light on factors that amplify the innate type-2 response, including TSLP, IL-25, and IL-33. Recent advancements in therapeutic strategies, specifically the utilization of biologics targeting pivotal cytokines (IL-4, IL-5, and IL-13), are discussed, offering insights into both challenges and opportunities.Acknowledging the pivotal role of innate type-2 cytokines in orchestrating immune responses positions them as promising therapeutic targets. The evolving landscape of research and development in this field not only propels immunological knowledge forward but also holds the promise of more effective treatments in the future.
