Patterns of Serum Interleukin-6 Concentration after Initial Successful Cardiopulmonary Resuscitation.
- Author:
Kyu Nam PARK
;
Seung Hyun PARK
;
Du Young HWANG
;
Hyung Guk KIM
;
Hwan LEE
;
Kyung Ho CHOI
;
Won Jae LEE
;
Uk Sung JUNG
;
Hak Ju KIM
;
Se Kyung KIM
- Publication Type:Original Article
- MeSH:
Cardiopulmonary Resuscitation*;
Enzyme-Linked Immunosorbent Assay;
Humans;
Interleukin-16;
Interleukin-6*;
Prospective Studies
- From:Journal of the Korean Society of Emergency Medicine
1998;9(4):571-577
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate patterns of serial serum interleukin-6(IL-6) concentrations after initial successful cardiopulmonary resuscitation, and to access differences in serum IL16 concentrations in patients with Cerebral Performance Category(CPC, 1-2) and CPC(3-5) at the 5th day after cardiacpulmonary resuscitation(CPR). METHODS: We studied prospectively 12 patients with spontaneous circulation after cardiopulmonary resuscitation. Venous blood samples were taken 2,4,12,24,48 and 72 hours after restoration of spontaneous circulation to measure serum IL-6 levels by the enzyme-linked immunosorbent assay. RESULTS: Serum IL-6 concentrations in the severe neurologically disabled group(CPC, 3-5) were significantly increased at 2, 24 and 48 hours after restoration of spontaneous circulation compared with the less neurolgically disabled group. Also, serum IL-6 concentrations in the severe neurologic disabled group showed dual peak at 4 and 24 hours. CONCLUSION: Our study demonstrates significant incense of seam IL-6 in patients with CPC(3-5) after successful cardiopulmonary resuscitation and the significant correlation between early increase of serum IL-6 and poor neurologic outcome. It suggests that early increase of serum IL-6 can be used as a prognostic marker after successful cardiopulmonary resuscitation.
