Research Progress of Central and Peripheral CorticotropinReleasing Hormone in Irritable Bowel Syndrome with Comorbid Dysthymic Disorders
- Author:
Yi Feng LIANG
1
;
Xiao Qi CHEN
;
Meng Ting ZHANG
;
He Yong TANG
;
Guo Ming SHEN
Author Information
- Publication Type:Review Article
- From:Gut and Liver 2024;18(3):391-403
- CountryRepublic of Korea
- Language:English
- Abstract: Irritable bowel syndrome (IBS) is considered a stress disorder characterized by psychological and gastrointestinal dysfunction. IBS patients not only suffer from intestinal symptoms such as abdominal pain, diarrhea, or constipation but also, experience dysthymic disorders such as anxiety and depression. Studies have found that corticotropin-releasing hormone plays a key role in IBS with comorbid dysthymic disorders. Next, we will summarize the effects of corticotropinreleasing hormone from the central nervous system and periphery on IBS with comorbid dysthymic disorders and relevant treatments based on published literatures in recent years.
