The Usefulness of 18 F-FDG PET to Differentiate Subtypes of Dementia:The Systematic Review and Meta-Analysis
- Author:
Seunghee NA
1
;
Dong Woo KANG
;
Geon Ha KIM
;
Ko Woon KIM
;
Yeshin KIM
;
Hee-Jin KIM
;
Kee Hyung PARK
;
Young Ho PARK
;
Gihwan BYEON
;
Jeewon SUH
;
Joon Hyun SHIN
;
YongSoo SHIM
;
YoungSoon YANG
;
Yoo Hyun UM
;
Seong-il OH
;
Sheng-Min WANG
;
Bora YOON
;
Hai-Jeon YOON
;
Sun Min LEE
;
Juyoun LEE
;
Jin San LEE
;
Hak Young RHEE
;
Jae-Sung LIM
;
Young Hee JUNG
;
Juhee CHIN
;
Yun Jeong HONG
;
Hyemin JANG
;
Hongyoon CHOI
;
Miyoung CHOI
;
Jae-Won JANG
;
On behalf of Korean Dementia Association
Author Information
- Publication Type:Original Article
- From:Dementia and Neurocognitive Disorders 2024;23(1):54-66
- CountryRepublic of Korea
- Language:EN
-
Abstract:
Background:and Purpose: Dementia subtypes, including Alzheimer’s dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of 18 F-Fluorodeoxyglucose Positron Emission Tomography ( 18 F-FDG PET) in differentiating these subtypes for precise treatment and management.
Methods:A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was conducted using databases like PubMed and Embase to identify studies on the diagnostic utility of 18 F-FDG PET in dementia. The search included studies up to November 16, 2022, focusing on peer-reviewed journals and applying the goldstandard clinical diagnosis for dementia subtypes.
Results:From 12,815 articles, 14 were selected for final analysis. For AD versus FTD, the sensitivity was 0.96 (95% confidence interval [CI], 0.88–0.98) and specificity was 0.84 (95% CI, 0.70–0.92). In the case of AD versus DLB, 18F-FDG PET showed a sensitivity of 0.93 (95% CI 0.88-0.98) and specificity of 0.92 (95% CI, 0.70–0.92). Lastly, when differentiating AD from non-AD dementias, the sensitivity was 0.86 (95% CI, 0.80–0.91) and the specificity was 0.88 (95% CI, 0.80–0.91). The studies mostly used case-control designs with visual and quantitative assessments.
Conclusions:18 F-FDG PET exhibits high sensitivity and specificity in differentiating dementia subtypes, particularly AD, FTD, and DLB. This method, while not a standalone diagnostic tool, significantly enhances diagnostic accuracy in uncertain cases, complementing clinical assessments and structural imaging.
