Transdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10
- Author:
Hedda SOLOEY-NILSEN
1
;
Kristin NYGAARD-ODEH
;
Magnhild Gangsoey KRISTIANSEN
;
Erling Inge KVIG
;
Ole Lars BREKKE
;
Tom Eirik MOLLNES
;
Michael BERK
;
Solveig Klaebo REITAN
;
Terje OIESVOLD
Author Information
- Publication Type:Original Article
- From:Clinical Psychopharmacology and Neuroscience 2024;22(2):285-294
- CountryRepublic of Korea
- Language:EN
-
Abstract:
Objective:Many psychiatric disorders are linked to low grade systemic inflammation as measured by systemic cytokine levels. Exploration of cytokines and immune activity and their role in psychiatric symptoms may inform pathobiology and treatment opportunities. The aim of this study is to explore if there are associations between cytokines and psychiatric symptom clusters. Comparison between patients regularly using and those not using psychotropic medication is also conducted.
Methods:This was a cross sectional naturalistic study with 132 participants from a general open inpatient psychiatric ward at the Nordland Hospital Trust, Norway. Serum levels of 28 different cytokines were assessed. Psychiatric symptoms the last week were assessed by a self-rating scale (Symptom check list, SCL-90-R) and grouped in defined clusters.Multiple linear regression model was used for statistical analyses of associations between levels of cytokines and symptoms, adjusting for possible confounding factors.
Results:We found a positive association (p = 0.009) between the chemokine interferon-gamma inducible protein 10 (CXCL 10; IP-10) and the anger hostility cluster. No associations were found between the other symptom clusters and cytokines. IP-10 and the anger hostility cluster were positively associated (p = 0.002) in the subgroup of patients using psychotropic medication, not in the subgroup not using psychotropic medication.
Conclusion:Our analyses revealed a significant positive association between the symptom cluster anger hostility in SCL-90-R and the chemokine IP-10 in the subgroup of patients using psychotropic medications.
