Association between Osteoporosis and Skeletal Muscle Mass in Men
- Author:
Masaya MIZUTANI
1
;
Yawara EGUCHI
;
Toru TOYOGUCHI
;
Sumihisa ORITA
;
Kazuhide INAGE
;
Yasuhiro SHIGA
;
Satoshi MAKI
;
Junichi NAKAMURA
;
Shigeo HAGIWARA
;
Yasuchika AOKI
;
Masahiro INOUE
;
Masao KODA
;
Hiroshi TAKAHASHI
;
Tsutomu AKAZAWA
;
Seiji OHTORI
Author Information
- Publication Type:Clinical Study
- From:Asian Spine Journal 2024;18(1):73-78
- CountryRepublic of Korea
- Language:EN
-
Abstract:
Methods:This study included 99 men (mean age, 74.9 years; range, 28–93 years) who visited Qiball Clinic for BMD and body composition examinations. The osteoporosis group consisted of 24 patients (mean age, 72.5 years; range, 44–92 years), and the control group consisted of 75 individuals (mean age, 74.9 years; range, 28–93 years). Whole-body skeletal muscle mass was measured using a bioelectrical impedance analyzer. BMD was measured by dual X-ray absorptiometry. Skin autofluorescence (SAF), a marker of dermal AGE accumulation, was measured using a spectroscope. Osteoporosis was defined as a bone density T score of –2.5 or less. Physical findings, skeletal muscle mass, BMD, grip strength, and SAF were compared between the osteoporosis and control groups.
Results:The osteoporosis group had significantly lower trunk muscle mass (23.1 kg vs. 24.9 kg), lower leg muscle mass (14.4 kg vs. 13.0 kg), and skeletal mass index (7.1 kg/m2 vs. 6.7 kg/m2) than the control group (all p<0.05). Lower limb muscle mass was identified as a risk factor for osteoporosis in men (odds ratio, 0.64; p=0.03).
Conclusions:Conservative treatment of osteoporosis in men will require an effective approach that facilitates the maintenance or strengthening of skeletal muscle mass, including exercise therapy with a focus on lower extremities and nutritional supplementation.
