Treatment of PDA in premature newborns with mefenamic acid.
10.12701/yujm.1993.10.2.506
- Author:
Jae Joon LEE
;
Young Hwan LEE
;
Son Moon SHIN
- Publication Type:Original Article
- MeSH:
Anoxia;
Dinoprostone;
Ductus Arteriosus;
Echocardiography;
Humans;
Infant, Newborn*;
Mefenamic Acid*;
Prostaglandin-Endoperoxide Synthases
- From:Yeungnam University Journal of Medicine
1993;10(2):506-511
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was conducted to examine the effect of mefenamic acid for treatment of PDA in premature newborns. Ductus arteriosus is reopened by locally produced prostaglandin E2 in a premature newborn during hypoxia. Mefenamic acid is one of non-steroidal antiinflammatory drugs acting by inhibition of cyclo-oxygenase in the prostaglandin synthesis pathway. For three premature newborns with PDA, we administered mefenamic acid and evaluated them with echocardiography to study the effect of mefenmic acid for closure of PDA. In all three babies, ductus arteriosus was closed successfully. We feel that mefenamic acid is safe and effective medication for treatment of PDA in premature newborns, but further-study need to be conducted with larger numbers of cases to confirm this effect.
