Diffuse alveolar damage during chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.
- Author:
Kyoung Ju LEE
1
;
Ki Hwan JUNG
;
In Keun CHOI
;
Je Hyeong KIM
;
Jae Hong SEO
;
Young Sik KIM
;
Chol SHIN
Author Information
1. Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea. chepraxis@korea.com
- Publication Type:Case Report
- Keywords:
Oxaliplatin;
Fluorouracil;
Leucovorin;
Drug toxicity;
Interstitial lung disease
- MeSH:
Diarrhea;
Drug Therapy*;
Drug Therapy, Combination;
Drug-Related Side Effects and Adverse Reactions;
Fluorouracil*;
Humans;
Leucovorin*;
Lung Diseases, Interstitial;
Neutropenia;
Stomach Neoplasms
- From:Korean Journal of Medicine
2006;71(1):86-90
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The combination chemotherapy of oxaliplatin with 5-fluorouracil and leucovorin (FOLFOX regimen) has been recently proved to be beneficial in advanced colorectal and gastric cancer. Side effects of this regimen include neutropenia, diarrhea, and neurosensory toxicity. However, the case reports about pulmonary toxicities of this regimen are very limited. Herein is the reported case of a patient treated with oxaliplatin, 5-fluorouracil and leucovorin combination chemotherapy in whom diffuse alveolar damage developed and the disease improved after steroid pulse therapy.
