BRAF-Mutated Colorectal Cancer Exhibits Distinct Clinicopathological Features from Wild-Type BRAF-Expressing Cancer Independent of the Microsatellite Instability Status.
10.3346/jkms.2017.32.1.38
- Author:
Min Hye JANG
1
;
Sehun KIM
;
Dae Yong HWANG
;
Wook Youn KIM
;
So Dug LIM
;
Wan Seop KIM
;
Tea Sook HWANG
;
Hye Seung HAN
Author Information
1. Department of Pathology, Konkuk University School of Medicine, Seoul, Korea. 20040002@kuh.ac.kr
- Publication Type:Original Article
- Keywords:
BRAF V600E;
Colorectal Cancer;
Clinicopathological Feature;
Microsatellite Instability
- MeSH:
Colorectal Neoplasms*;
Humans;
Incidence;
Microsatellite Instability*;
Microsatellite Repeats*;
Mucins
- From:Journal of Korean Medical Science
2017;32(1):38-46
- CountryRepublic of Korea
- Language:English
-
Abstract:
In patients with colorectal cancer (CRC), the BRAF V600E mutation has been reported to be associated with several clinicopathological features and poor survival. However, the prognostic implications of BRAF V600E mutation and the associated clinicopathological characteristics in CRCs remain controversial. Therefore, we reviewed various clinicopathological features, including BRAF status, in 349 primary CRCs and analyzed the relationship between BRAF status and various clinicopathological factors, including overall survival. Similar to previous studies conducted in Eastern countries, the incidence of the BRAF V600E mutation in the current study was relatively low (5.7%). BRAF-mutated CRC exhibits distinct clinicopathological features from wild-type BRAF-expressing cancer independent of the microsatellite instability (MSI) status. This mutation was significantly associated with a proximal tumor location (P = 0.002); mucinous, signet ring cell, and serrated tumor components (P < 0.001, P = 0.003, and P = 0.008, respectively); lymphovascular invasion (P = 0.004); a peritumoral lymphoid reaction (P = 0.009); tumor budding (P = 0.046); and peritoneal seeding (P = 0.012). In conclusion, the incidence of the BRAF V600E mutation was relatively low in this study. BRAF-mutated CRCs exhibited some clinicopathological features which were also frequently observed in MSI-H CRCs, such as a proximal location; mucinous, signet ring cell, and serrated components; and marked peritumoral lymphoid reactions.
