Optimization of the Extraction Process for Bioactive Compounds from the Root Barks of Moringa oleifera
- Author:
Do Hoang GIANG
1
;
Tran Van HIEN
;
Nguyen Thi THU MINH
;
Nguyen Thu UYEN
;
Hoang Thuy DUONG
;
Bui Thi NHAT LE
;
Mai Thi THU HA
;
Nguyen Tien DAT
Author Information
- From:Natural Product Sciences 2023;29(4):281-286
- CountryRepublic of Korea
- Language:English
- Abstract: The optimal condition for Moringa oleifera root barks extraction was determined using response surface methodology and Box-Behnken Design. The actual optimal condition of the factors was 65 o C, ethanol 60%, 40 (mL/g) liquid-to-solid ratio with 240 minutes extraction time. The enrichment of phenolic compounds sharply affected the antioxidant, and inhibitions of α-amylase enzyme, as well as, the anti-inflammatory effect of the extract from M. oleifera root barks. The extract in the optimal condition exhibited better 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and α-amylase inhibitory activities than those of positive controls.Also, the extract showed weak hydroxyl free radical scavenging and nitric oxide (NO) production inhibitory effects. These revealed a simple and promising method for the preparation of bioactive products from the root bark of M. oleifera.
