Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg
- Author:
Mulyadi TANJUNG
1
;
Tjitjik Srie TJAHJANDARIE
;
Muhammad Fajar ALDIN
;
Shola MARDHIYYAH
;
Norizan AHMAT
;
Ratih Dewi SAPUTRI
Author Information
- From:Natural Product Sciences 2023;29(4):287-290
- CountryRepublic of Korea
- Language:English
- Abstract: A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and highresolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa cells.Compound 1 showed potent activity against 4T1 cells with an IC 50 value of 1.18 μg/mL, and compound 3 showed moderate activity against P-388 cells (IC 50 value of 2.54 μg/mL).
