Establishment of an image evaluation grading criteria for experimental stifle joint osteoarthritis in dogs: an X‑ray and CT imaging study
10.1186/s42826-023-00186-z
- Author:
Beomseok RHEE
1
;
Changfan JIN
;
Seo‑Hyun SHIN
;
Hojung CHOI
;
Youngwon LEE
;
Sokho KIM
Author Information
1. Research Center, HLB BioStep Co., Ltd., Incheon 22014, Republic of Korea
- Publication Type:RESEARCH
- From:Laboratory Animal Research
2023;39(4):395-401
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:This study aimed to establish an image evaluation grading criteria for experimental stifle joint osteoar‑ thritis (OA) in anterior cruciate ligament transection induced OA beagle dog models. The severity of OA was assessed using X-ray and computed tomography (CT) imaging.
Results:A total of 32 dogs (8 controls and 24 OA-induced dogs) were included in the study. The OA-induced group showed significantly higher manual joint palpation, gait analysis, and OA severity scores than the control group. Based on these two results, we calculated correlation coefficients. There was a strong positive correlation between manual joint palpation scores and OA severity on diagnostic imaging and between gait analysis scores and OA severity.
Conclusions:The developed grading criteria based on radiographic evaluation correlated with clinical assessments. The study also employed CT imaging to enhance the accuracy and sensitivity of early-stage OA change detec‑ tion in the stifle joint. However, further studies with larger sample sizes and multiple evaluators are recommended for the validation and generalizability of this grading system. These established image evaluation grading criteria can help evaluate and monitor the efficacy of interventions and changes in OA lesions in canine models.
