Sclerosing Angiomatoid Nodular Transformation (SANT) in Spleen: A Case Report.
- Author:
Hyun Jung LEE
1
;
Song Yi CHOI
;
Song Mei HUANG
;
Ji Young SUL
;
Jin Man KIM
Author Information
1. Department of Pathology, Chungnam National University College of Medicine, Daejeon, Korea. jinmank@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
Spleen;
Hamartoma;
Antigens, CD31
- MeSH:
Actins;
Antigens, CD31;
Collagen;
Female;
Fibroblasts;
Follow-Up Studies;
Hamartoma;
Humans;
Lymphoma;
Middle Aged;
Muscles;
Phosphotransferases;
Receptor Protein-Tyrosine Kinases;
Recurrence;
Spleen;
Splenectomy
- From:Korean Journal of Pathology
2011;45(1):111-114
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sclerosing angiomatoid nodular transformation (SANT) of spleen is a rare inflammatory tumor-like vascular lesion composed of angiomatoid nodules in a fibrosclerotic background. We report herein on a case of SANT in the spleen with its pathologic features, and review the related literature. A 50-year-old woman presented with mild left upper quadrant discomfort and tenderness and she showed a 6 cm-sized solitary splenic mass on computed tomography. She underwent laparoscopic splenectomy. Grossly, the spleen showed a well circumscribed round-shaped solid mass with multinodular hemorrhagic surfaces. Microscopically, the mass consisted of multiple angiomatoid nodules surrounded by collagen bundles with fibroblasts and a lymphoplasma cell infiltration. Immunohistochemically, the cells of the angiomatoid nodules were positive for CD31, CD30, CD34, alpha-smooth muscle actin, and VWF-VIII, but they were negative for CD8, anaplastic lymphoma kinase protein, and D2-40. The patient has been under close follow-up without recurrence.
