Simultaneous hypersensitivity reactions to trimethoprimsulfamethoxazole and amoxicillinclavulanate in a dog
- Author:
Yunho JEONG
1
;
Yoon-Hwan KIM
;
Jin-Ok AHN
;
Jin-Young CHUNG
Author Information
- Publication Type:Case Report
- From:Journal of Veterinary Science 2023;24(6):e77-
- CountryRepublic of Korea
- Language:English
- Abstract: Antibiotics are known to be able to cause hypersensitivity reactions through various mechanisms. We present a case of drug-induced immune thrombocytopenia (DITP) and anaphylactic shock occurring simultaneously in a dog after the administration of two classes of antibiotics, namely trimethoprim-sulfamethoxazole (TMP-SMX) and amoxicillinclavulanate (AMC). The patient recovered completely from DITP on discontinuation of TMP-SMX and the anaphylactic shock caused by AMC was treated with intensive care. DITP is a rare adverse drug reaction (ADR), and anaphylactic shock is a life-threatening ADR. This is the first case report of a dog manifesting two types of hypersensitivity reactions caused by two antibiotics.
