Lineage Switch Subsequently Developed after Isolated Extramedullary Relapse in Children with Acute Myeloid Leukemia
10.15264/cpho.2023.30.2.70
- Author:
Yee Rae PARK
1
;
Eu Jeen YANG
;
Ju Kyung HYUN
;
Ina JEONG
;
In-Sook KIM
;
Young Tak LIM
Author Information
1. Department of Pediatrics, Pusan National University Children’s Hospital, Pusan National University School of Medicine, Yangsan, Korea
- Publication Type:CASE REPORT
- From:Clinical Pediatric Hematology-Oncology
2023;30(2):70-74
- CountryRepublic of Korea
- Language:English
-
Abstract:
Isolated extramedullary relapse (EMR) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in acute myeloid leukemia (AML) is relatively rare and the clinical significance is still not well characterized, particularly in children. During or after chemotherapy, an uncommon event termed lineage switch, in which the lineage at onset of leukemia converts to another lineage at a later time, is observed in a subset of leukemia patients, but it is a rare event. We report a 10-year-old boy with isolated mediastinal EMR after allo-HSCT for AML who subsequently experienced BM relapse with the cell lineage switching from AML to T-cell acute lymphoblastic leukemia.
