Recent advances in cellular immunotherapy for lymphoid malignancies
- Author:
Haerim CHUNG
1
;
Hyunsoo CHO
Author Information
- Publication Type:REVIEW ARTICLE
- From:Blood Research 2023;58(4):166-172
- CountryRepublic of Korea
- Language:English
- Abstract: Cellular immunotherapy with chimeric antigen receptor (CAR) T-cells has revolutionized the treatment of lymphoid malignancies. This review addresses the need for CAR expression in our endogenous T-cells to kill tumor cells with a focus on the basic principles of T-cell receptor recognition of major histocompatibility complex-peptide complexes.We review the factors associated with CAR T-cell outcomes and recent efforts to employ CAR T-cells in earlier lines of therapy. We also discuss the value of bispecific T-cell engagers as off-the-shelf products with better toxicity profiles. Finally, natural killer cells are discussed as an important cellular immunotherapy platform with the potential to broaden immunotherapeutic applications beyond lymphoid malignancies.
