A Survey on QT Correction for Methadone Administration

Asako Koshibu; Takashi Igarashi; Maho Nakamura; Tomofumi Miura; Naoko Kumazawa

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A Survey on QT Correction for Methadone Administration

VernacularTitle:メサドン投与時のQT補正値に関する実態調査
Author: Asako KOSHIBU ¹ ; Takashi IGARASHI ¹ ; Maho NAKAMURA ¹ ; Tomofumi MIURA ² ; Naoko KUMAZAWA ¹
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1. Department of Pharmacy, National Cancer Hospital East
2. Department of Palliative Medicine, National Cancer Center Hospital East
Keywords: methadone; QT correction; Bazett formula; Fridericia formula
From:Palliative Care Research 2024;19(3):157-162
CountryJapan
Language:Japanese
Abstract: We investigated the impact of Bazett (B) and Fridericia (F) correction formulas on the evaluation of QT prolongation in patients during methadone administration and to explore the relationship between heart rate and corrected QT interval (QTc) according to both correction formulas. This study was conducted as a single-center, retrospective observational study. Subjects were cancer patients who underwent electrocardiographic evaluation for methadone therapy at our institute from April 1, 2013, to August 31, 2023. The study assessed the incidence of QT prolongation and analyzed the correlation between heart rate and QTc derived from the B and F formulas. The mean QTc of 430.3±25.8 msec for the B formula and 409.2±20.8 msec for the F formula. The incidence of QT prolongation was significantly lower with the F formula (8.4%) compared to the B formula (27.7%), indicating a 19.3% reduction in QT prolongation cases (p<0.001). Additionally, the difference in QTc between the two formulas increased with an increase in heart rate (p<0.001). These results suggest that the F formula for QT interval correction in methadone therapy potentially expands the eligible patients for this therapy.