Research Progress of Acupuncture in Improving Central Nervous System Diseases by Regulating BDNF/TrkB Signaling Pathway
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240617.002
- VernacularTitle:针刺调节BDNF/TrkB信号通路改善中枢神经系统疾病的研究进展
- Author:
Wenjing LI
1
;
Yanjie BAI
Author Information
1. 河南中医药大学,河南 郑州 450046
- Keywords:
acupuncture;
BDNF/TrkB signaling pathway;
central nervous system diseases;
ischemic stroke;
Alzheimer's disease;
Parkinson's disease;
spinal cord injury;
mechanism of action
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(4):530-538
- CountryChina
- Language:Chinese
-
Abstract:
As a key regulator of neuronal growth,development and synaptic plasticity,BDNF/TrkB signaling path-way is widely involved in the occurrence and development of central nervous system diseases,such as ischemic stroke,Al-zheimer's disease,Parkinson's disease and spinal cord injury.Studies have shown that acupuncture can regulate the activi-ty of BDNF/TrkB signaling pathway,and has significant therapeutic potential for these diseases.Its mechanism of action is related to participating in synaptic remodeling,inhibiting neuronal apoptosis,and promoting neurogenesis or synaptic re-generation.This article reviews the role of BDNF/TrkB signaling pathway in central nervous system diseases and the regula-tion mechanism of acupuncture on this pathway,in order to provide new ideas for clinical treatment.Future studies should further explore the precise regulatory mechanism of acupuncture on BDNF/TrkB signaling pathway in order to develop more efficient and safe treatment strategies.
