Research Progress of Acupuncture in Improving Central Nervous System Diseases by Regulating BDNF/TrkB Signaling Pathway
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240617.002
- VernacularTitle:针刺调节BDNF/TrkB信号通路改善中枢神经系统疾病的研究进展
- Author:
Wenjing LI
1
;
Yanjie BAI
2
Author Information
1. Henan University of Traditional Chinese Medicine， Zhengzhou， Henan 450046， China
2. The First Affiliated Hospital of Henan University of Traditional Chinese Medicine， Zhengzhou， Henan 450000， China
- Publication Type:Review
- Keywords:
acupuncture;
BDNF/TrkB signaling pathway;
central nervous system diseases;
ischemic stroke;
Alzheimer's disease;
Parkinson's disease;
spinal cord injury;
mechanism of action
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(4):530-538
- CountryChina
- Language:Chinese
-
Abstract:
As a key regulator of neuronal growth， development and synaptic plasticity， BDNF/ TrkB signaling pathway is widely involved in the occurrence and development of central nervous system diseases， such as ischemic stroke， Alzheimer's disease， Parkinson's disease and spinal cord injury. Studies have shown that acupuncture can regulate the activity of BDNF/TrkB signaling pathway， and has significant therapeutic potential for these diseases. Its mechanism of action is related to participating in synaptic remodeling， inhibiting neuronal apoptosis， and promoting neurogenesis or synaptic regeneration. This article reviews the role of BDNF/TrkB signaling pathway in central nervous system diseases and the regulation mechanism of acupuncture on this pathway， in order to provide new ideas for clinical treatment. Future studies should further explore the precise regulatory mechanism of acupuncture on BDNF/TrkB signaling pathway in order to develop more efficient and safe treatment strategies.
