.Correlation between cognitive impairment in Alzheimer’s disease and uric acid and homocysteine
- VernacularTitle: 阿尔茨海默病患者认知损害与尿酸同型半胱氨酸的相关性研究
- Author:
Ting PAN
1
;
Qiqiang TANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Alzheimer’s disease; Cognitive function; Homocysteine; Uric acid
- From: Journal of Apoplexy and Nervous Diseases 2020;37(2):138-141
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the relationship between cognitive impairment of Alzheimer’s disease and serum Uric acid (UA) and Homocysteine (Hcy) concentrations in the patients.Method We collected 39 cases of geriatric cognitive impairment hospitalized in the department of neurology of anhui provincial hospital from September 2018 to May 2019,and 22 normal control cases with no significant differences in age,gender and education level，the levels of serum uric acid and homocysteine were measured in both groups,and neuropsychological tests including MMSE and MoCA were conducted.Results The MMSE score (17.54±4.71) and MoCA score (11.41±4.48) of the case group were lower than that of the control group MMSE score (27.82±1.84) and MoCA score (23.27±3.23),the difference between the two groups was statistically significant (t=9.801,P<0.05,t=10.895,P<0.05) in the case group,UA was 325.16±80.19,Hcy was 14.37±7.37,in the control group,UA was 258.47±71.06,and Hcy was 8.91±2.61.The differences between the two groups were statistically significant (t=-3.246,P<0.05,Z=4.316,P<0.05);Hcy level was negatively correlated with MMSE and MoCA(R=-0.490,P<0.05).The UA value in the case group was positively correlated with MMSE and MoCA (R=0.573,P<0.05,R=0.624,P<0.05).Conclusion Hyperhomocysteine is a risk factor for cognitive impairment,which is positively correlated with cognitive function.UA is positively correlated with patients cognitive function,especially with visual space and executive ability,and uric acid level may be related to the disease process of cognitive impairment.
- Full text:2024080215293746875阿尔茨海默病患者认知损害与尿酸同型半胱氨酸的相关性研究.pdf
