MiR-134 expression in peripheral blood in patients with epilepsy
- VernacularTitle:癫痫患者外周血miR-134表达及意义
- Author:
Xiaoshuang WANG
1
;
Qi GUO
1
;
Yafei ZHU
1
Author Information
- Publication Type:Journal Article
- Keywords: MiRNAs; MiR-134; Synaptic plasticity; Temporal lobe epilepsy
- From: Journal of Apoplexy and Nervous Diseases 2020;37(2):154-157
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the difference and significance in the expression of miR-134 in peripheral blood of patients with epilepsy.Methods Trizol was used to extract serum RNAs of patients with epilepsy,NCode TM VILO TM micrornas cDNA short Kit and Express Sybr those TM micrornas qRTPCR Kits was used to reverse transcriptions and real-time fluorescent quantitative PCR to detect the expression of miR-134.All cases were grouped according to the course of disease,seizure frequency,onset time limit,brain electrical activity and special epilepsy syndrome.Results Compared with control group,the expression of miR-134 in peripheral blood of epilepsy group is significantly increased,it is obviously higher in long course group and acute group.The expression of miR-134 in different seizure frequency group and special epilepsy syndrome group has no difference.Conclusion The expression of miR-134 in peripheral blood of patients with epilepsy was significantly increased while it was affected by the length of disease and the duration of seizure.In addition,the expression of miR-134 in peripheral blood of patients with epilepsy was positively correlated with the degree of discharge and severity of damage,indicating that miR-134 could be a biomarker for epilepsy.
- Full text:2024080215225952773MiR-134 expression in peripheral blood in patients with epilepsy.pdf
