Clinical characteristics of 30 patients with gamma-aminobutyric acid-B receptor (GABAB) encephalitis
- VernacularTitle: 30例抗γ氨基丁酸B受体脑炎临床特点分析
- Author:
Qiaoman ZHANG
1
;
Chengze WANG
1
;
Congcong Ma
1
Author Information
- Publication Type:Journal Article
- Keywords: Seizures; Mental and behavioral disorders; Lung cancer; Anti GABA-B encephalitis
- From: Journal of Apoplexy and Nervous Diseases 2020;37(2):150-153
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the characteristics of clinical presentations，cerebrospinal fluid (CSF),magnetic resonance imaging (MRI) and prognosis of the anti-GABA-B receptor encephalitis.Methods The clinical data of 30 patients with anti-GABA-B receptor encephalitis were collected.To analysis the characteristics of clinical features，CSF,cranial MRI features and prognosis.Results Among the 30 patients,eighteen were male,and the mean age at presentation were 58 years (range:15~84 years).Seizure was the most common initial symptom.The major clinical features include seizure (26,86.67%),mental and behavioral disorders (26,86.67%),cognitive dysfunction (24,80.00%).CSF cytology test showed that the lymphocytic pleocytosis and the elevated white blood cell counts can be indicative of this disease.Magnetic resonance imaging showed abnormality in the medial temporal lobe and hippocampus in ten patients （35.71%).The disease is closely related to lung cancer (Especially small cell lung cancer,SCLC).During a median follow-up period of 11 months,thirteen patients died.Nine of the patients died with tumors.Conclusions The major clinical features of anti GABA-B encephalitis was seizures.Inflammatory response signals in the medial temporal lobe and hippocampus are image features of this disease.It is closely related to lung cancer (Especially small cell lung cancer,SCLC).Almost half of the patients had poor outcome.
- Full text:2024080215210490951Clinical characteristics of 30 patients with gamma-aminobutyric acid-B receptor GABAB) encephalitis.pdf
