Meta-analysis of butylphthalide soft capsules combined with aspirin in treatment of acute cerebral infarction
- VernacularTitle: 丁苯酞软胶囊联合阿司匹林治疗急性脑梗死的Meta分析
- Author:
Jingmin KONG
1
;
Changying LIU
1
;
Shanshan ZHU
1
Author Information
- Publication Type:Journal Article
- Keywords: Butylphthalide soft capsules; Aspirin; Acute cerebral infarction; Meta-analysis
- From: Journal of Apoplexy and Nervous Diseases 2020;37(2):118-122
- CountryChina
- Language:Chinese
- Abstract: Objective To evaluate the efficacy and safety of butylphthalide combined with aspirin in treatment of acute cerebral infarction.Methods CNKI,Wanfang,VIP,sinomed,PubMed,Cochrane library databases were searched by computer from the building time to October 2019.According to the inclusion and exclusion criteria,the eligible RCT was selected and Meta-analysis was carried out by Revman 5.3 soft ware.Results A total of 1375 cases were included in 15 articles.The results from Meta-analysis demonstrated that the cure rate of the treatment group was superior to that of the single drug ［RR=1.56,95% CI (1.16,2.10),Z=2.93 (P=0.003)］,additional other treatments［RR=1.99,95% CI(1.30,3.05),Z=3.16(P=0.002)］;the effective rate of the treatment group was superior to that of the single drug［RR=1.41,95%CI(1.22,1.64),Z=4.52(P<0.00001)］,additional other treatments［RR=1.24,95%CI(1.12,1.38),Z=4.07(P<0.0001)］;the NHISS score of the treatment group was lower than that of the single drug［MD=-2.79,95%CI(-3.72,-1.86),Z=5.86(P<0.00001)］,additional other treatments［MD=-2.70,95%CI(-3.54,-1.85),Z=6.26(P<0.00001)］.There was no significant difference in safety between the two groups.Conclusion Butylphthalide combined with aspirin is effective and safe in the treatment of acute cerebral infarction.
- Full text:2024080214412420538Meta-analysis of butylphthalide soft capsules combined with aspirin in treatment of acute cerebral infarction.pdf
