Correlation between serum uric acid level and red cell distribution width in patients with acute ischemic stroke
- VernacularTitle:急性脑梗死患者血清尿酸水平与红细胞分布宽度的相关性分析
- Author:
Pei ZHAO
1
;
Jian YUAN
1
;
Baoguo LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Stroke; Serum uric acid level; Erythrocytehemoglobindistribution width; Correlation
- From: Journal of Apoplexy and Nervous Diseases 2020;37(3):251-254
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the relationship between serum uric acid（SUA） level and red cell distribution width in patients with acute ischemic stroke（AIS） and its clinical significance. Methods The clinical and biochemical data were retrospectively analyzed in 481 patients with AIS in the department of neurology at Renji Hospital Baoshan branch affiliated to Shanghai Jiao Tong University from January 2018 to June 2019.Included patients were divided into normal SUA group and high SUA group according to the SUA levels，and the clinical and biochemical characteristics between the two groups were compared. The correlation between SUA level and red cell distribution width was analyzed. Results There were no significant difference in gender，age，previous medical history（hypertension，diabetes mellitus，coronary heart disease etc.），total cholesterol，low density lipoprotein，red blood cell count，hemoglobin，erythrocyte aggregation index，mean corpuscular hemoglobin，erythrocyte rigidity index，glutamic-oxiracetam transaminase，cysteine level，erythrocyte sedimentation rate，D-dimer，white blood cell，antiplatelet，hypoglycemic，antihypertensive drugs between normal serum uric acid level group and high serum uric acid level group（P>0.05）. There was significant difference in uric acid，creatinine，urea，triglyceride，high density lipoprotein level，erythrocyte hemoglobin distribution width and mean corpuscular volume，red cell distribution width（P<0.05）. The relationship between the serum uric acid level and the red cell distribution width was u-shape. When SUA levels were within the normal range，serum uric acid levels were negatively correlated with red cell distribution width（r=-0.113，P=0.023）. When serum uric acid levels were high，the SUA were positively correlated with red cell distribution width（r=0.380，P<0.001）. Conclusion The red cell distribution width was increased with high SUA level in patients with AIS. The above findings were helpful to explore the possible mechanism of high SUA in promoting AIS by influencing the red blood cell deformation function.
- Full text:202408021218574877Correlation between serum uric acid level and red cell distribution width in patients with acute ischemic stroke.pdf
