A randomized controlled study of executive function differences in patients with Parkinson’s disease and multi-system atrophy
- VernacularTitle:帕金森病及多系统萎缩患者执行功能差异性的随机对照研究
- Author:
Heyun CHENG
1
;
Xingjuan ZHAO
1
;
Min ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Parkinson’s disease; Multiple system atrophy; Cognitive function; Executive dysfunction
- From: Journal of Apoplexy and Nervous Diseases 2020;37(3):247-250
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the differences and similarities of cognitive impairment，especially executive function，between patients with Parkinson’s disease（PD） and multi-system atrophy（MSA） by neuropsychological tests. Methods 26 patients with Parkinson’s disease，18 with multi-system atrophy and 20 with normal control were selected continuously. Age，education degree and course of disease were collected in detail. Montreal Cognitive Assessment （MoCA），Trail Making Test （TMT），Stroop Color-Word Test，Clock Drawing Test （CDT） and Rey-Osterriche complex figure test were given to evaluate cognitive and executive function of 26 patients with PD，18 patients with MSA and 20 normal controls randomly selected. Results Parkinson’s disease group and multi-system atrophy group had significantly lower scores in each test than the control group （P<0.05）. In the MOCA test，the scores of Parkinson’s patients were significantly lower than those of the multi-system atrophy group，［（22.34±3.18） vs（24.31±1.68），P<0.05]. The number of errors in the Stroop chromatogram test in Parkinson’s group was higher than that in the multi-system atrophy group［（10.74±6.31） vs（8.26±4.62），P<0.05]. In the remaining tests，there was no significant difference between PD and MSA patients （P>0.05）. Conclusion Parkinson’s disease patients and multi-system atrophy patients have different degrees of cognitive impairment and executive function decline than the normal population，Multisystem atrophy in terms of overall cognitive impairment is worse in patients with Parkinson’s disease than in patients with Parkinson’s disease，Parkinson’s disease patients have more attention deficit and more severe system atrophy，while patients with multiple system atrophy are more likely to have decreased self-examination ability and error correction ability.
- Full text:202408021227134946帕金森病及多系统萎缩患者执行功能差异性的随机对照研究.pdf
