Correlation between cerebral artery stenosis，plasma HCY level and MTHFR C677T gene polymorphism in ischemic young stroke patients
- VernacularTitle:缺血性青年脑卒中脑动脉狭窄与血浆HCY水平及MTHFR C677T基因多态性的相关性研究
- Author:
Qingyang CAO
1
;
Yu GAO
1
;
Zhijie NING
1
Author Information
- Publication Type:Journal Article
- Keywords: Ischemic youth stroke; Cerebral artery stenosis; HCY; C677T; Gene polymorphism
- From: Journal of Apoplexy and Nervous Diseases 2020;37(3):237-241
- CountryChina
- Language:Chinese
- Abstract: Objective To study the relationship between cerebral artery stenosis and homocysteine（HCY） level and methylenetetrahydrofolate reductase（MTHFR）C677T gene polymorphism in ischemic youth stroke. Methods 50 patients with ischemic young stroke were randomly selected from department 2 of neurology，China-Japan Union Hospital of Jilin University，41 of whom met the inclusion criteria. They were divided into stenosis group（20 cases） and non-stenosis group（21 cases） according to the presence or absence of cerebrovascular stenosis. The plasma HCY level and MTHFR C677T gene polymorphism were measured and analyzed statistically. Results In 41 patients，HCY level CC genotype（10.61±2.66）μmol/L was lower than TT genotype（19.65±14.43）μmol/L（P=0.033） and CT+TT genotype（16.65±12.48）μmol/L（P=0.015）. HCY levels in cerebral artery stenosis group and non-stenosis group were（20.44±14.70）μmol/L，（11.03±4.40）μmol/L（P=0.012） respectively（P= 0.012）. The level CC genotype 12.23±2.18 μmol/Lof HCY in stenosis group was lower than TT genotype（28.55±16.82）μmol/L（P=0.043） and CT+TT genotype（22.48±15.82）μmol/L（P=0.023）. The HCY level of CC genotype（8.46±1.40）μmol/L in non-stenosis group was lower than that of TT genotype（11.86±5.0）μmol/L（P=0.161） and CC+TT genotype（11.46±4.60）μmol/L（P=0.048）. The level of the same genotype HCY in the two groups was（28.55±16.82）μmol/L，（11.86±5.02）μmol/L（P=0.040），the CC genotype was（12.23±2.18）μmol/L，（8.46±1.40）μmol/L（P=0.049），and the CT genotype was（17.77 ±14.12）μmol/L，（11.14±4.48）μmol/L（P=0.178）. TT，CT and CT+TT genotypes of MTHFR C677T in the two groups were respectively compared with CC genotype P>0.05，and T was compared with C allele P>0.05. Logistic regression analysis showed that HCY（OR=1.168，95%CI 1.015～1.344，P=0.030） was a risk factor for cerebrovascular stenosis. Conclusion The level of HCY is a high risk factor for cerebral artery stenosis in ischemic young stroke patients. TT genotype of MTHFR C677T is the key factor affecting plasma HCY level，but C677T genotype and allele frequency have no direct correlation with cerebral artery stenosis.
- Full text:202408021200524004缺血性青年脑卒中脑动脉狭窄与血浆HCY水平及MTHFR C677T基因多态性的相关性研究.pdf
