Expression and clinical significance of α2-macroglobulin in cerebrospinal fluid of schizophrenic patients after cerebral infarction
10.19845/j.cnki.zfysjjbzz.2020.0340
- VernacularTitle: α2巨球蛋白在脑梗死后精神病性障碍患者脑脊液中的表达及临床意义
- Author:
Jianhua KOU
1
;
Tao LI
1
Author Information
1. Jian an Hospital of Xuchang City,Xuchamg 461000,China
- Publication Type:Journal Article
- Keywords:
α2-macroglobulin ； Cerebral infarction ； Psychotic disorder ； Cerebrospinal fluid ； Clinical significance
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(4):358-361
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of α2-macroglobulin (α2MG) in cerebrospinal fluid of schizophrenia patients after cerebral infarction.Methods One hundred and thirty-six psychotic disorder patients were selected from March 2015 to March 2019,including 53 patients with traumatic cerebral infarction (cerebral infarction group) and 83 patients with non-cerebral infarction (non cerebral infarction group).The levels of α2MG,interleukin-6 (IL-6),C-reactive protein (CRP),immunoglobulin M (IgM) and complement C3 were detected by enzyme-linked immunosorbent assay (ELISA),the correlations between α2MG and IL-6,CRP,IgM,C3 were analyzed;and the ROC curve was drawn to analyze the diagnostic value of serum α2MG level in schizophrenia after cerebral infarction.Results The levels of α2MG,IL-6,CRP,C3 and IgM in cerebrospinal fluid of patients in cerebral infarction group were higher than those of patients in non-cerebral infarction group (P<0.05).Pearson analysis showed that the levels of α2MG in cerebrospinal fluid were positively correlated with the levels of IL-6,CRP,C3 and IgM (r=0.413,P=0.002;r=0.553,P=0.000;r=0.613,P=0.000;r=0.512,P=0.000).ROC curve showed that the area under the curve of α2MG level in cerebrospinal fluid for the diagnosis of psychotic disorder after cerebral infarction was 0.897,the cutoff value was 1.968 μg/ml,the sensitivity was 83.0%,the specificity was 94.0%,and the 95% CI was 0.828~0.967.Conclusion The levels of α2MG in cerebrospinal fluid of psychotic disorder patients after cerebral infarction rises,which has certain clinical significance for the diagnosis of cerebral infarction psychotic disorder.
- Full text:2024080211385174366Expression and clinical significance of α2-macroglobulin in cerebrospinal fluid of schizophrenic patients after cerebral infarction.pdf
