The research on the mechanism of action of astrocytes in the rat with Parkinson’s disease
- VernacularTitle:星形胶质细胞在帕金森大鼠中的作用机制研究
- Author:
Chengjia LI
1
;
Lihong QIN
1
;
Chengze LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Astrocytes ； Parkinson’s disease ； Monoamine neurotransmitter
- From: Journal of Apoplexy and Nervous Diseases 2020;37(4):326-329
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze role of astrocytes and mechanisms on Parkinson’s disease in rats by analyzing the behavior changes and the changes of monoamine neurotransmitter in rat with Parkinson’s disease who were transplanted astrocytes.Methods To test behavior change,and detect monoamine neurotransmitter (DA,DOPAC and HVA) changes in the PD+T2As group and PD group in two weeks after transplant astrocytes to the PD rat striatum.Results The behavior of mice in PD+T2As group was improved significantly compared to mice in PD group after 4 weeks (P<0.01),and the levels of monoamine neurotransmitter (DA,DOPAC and HVA) were significantly higher than those in PD group in 3 weeks (P<0.01).Conclusion Astrocytes have repair and protective role in PD via the nigra striatum pathways.
- Full text:2024080211225135221星形胶质细胞在帕金森大鼠中的作用机制研究.pdf
