Relationship between IL-23R gene polymorphism and carotid atherosclerosis and vulnerability of carotid plaque in patients with ischemic stroke
10.19845/j.cnki.zfysjjbzz.2020.0327
- VernacularTitle: 缺血性卒中患者IL-23受体基因多态性与颈动脉粥样硬化及斑块易损性的相关性研究
- Author:
Yuanxue GAO
1
;
Zhihao XU
1
;
Jiangang LI
1
Author Information
1. Department of Neurology,Baioji Central Hospital,Baoji 721000,China
- Publication Type:Journal Article
- Keywords:
Ischemic stroke ； Interleukin-23 receptor ； Gene polymorphism； Carotid atherosclerosis ； Vulnerability of plaque
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(4):306-309
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between IL-23R gene polymorphism and carotid atherosclerosis and vulnerability of carotid plaque in patients with ischemic stroke.Methods A total of 460 patients with ischemic stroke hospitalized in our department from January 2019 to October 2019 were recruited in this study.The patients were divided into non-plaque group (112 cases),stable plaque group (164 cases) and vulnerable plaque group (184 cases),according to the results of carotid ultrasonography.Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism for the IL-23R gene rs6682925 polymorphism.Results The genotype and allele frequencies of rs6682925 in stable plaque group and vulnerable plaque group were significantly different from non-plaque group (P＜0.05).There was no significant difference in genotype and allele frequencies of rs6682925 between stable plaque group and vulnerable plaque group (P＞0.05).After adjusting risk factors (age,FIB，HCY and diabetes),the risk of rs6682925 CC genotype carriers suffer from carotid atherosclerotic plaque was 2.616 times that of TT genotype (95%CI 1.399~4.904,P=0.001).Conclusions IL-23R rs6682925 gene polymorphism is associated with carotid atherosclerosis,and the rs6682925 CC genotype might act as a risk factor for carotid atherosclerosis plaque.However,rs6682925 gene polymorphism may not associated with vulnerability of carotid plaque.
- Full text:2024080211104364587Relationship between IL-23R gene polymorphism and carotid atherosclerosis and vulnerability of carotid plaque in patients with ischemic stroke.pdf
