The relationships between the levels of serum mir-210 and HIF-1α and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
10.19845/j.cnki.zfysjjbzz.2020.0326
- VernacularTitle:血清mir-210、HIF-1α水平与动脉瘤性蛛网膜下腔出血后迟发性脑缺血的关系
- Author:
Na WANG
1
;
Yujie BIAN
1
;
Jixin TIAN
1
Author Information
1. Department of Surgery,the Ninth People Hospital of Zhengzhou City，Zhengzhou 450053,China
- Publication Type:Journal Article
- Keywords:
Aneurysmal subarachnoid hemorrhage ； Delayed cerebral ischemia； microRNA-210 ； Hypoxia inducible factor-1α
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(4):302-305
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationships between serum microRNA-210 (mir-210),hypoxia inducible factor-1α (HIF-1α) and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH).Methods Two hundred and sixty patients with aSAH who were diagnosed and treated in the Department of Neurosurgery of our hospital were selected as the study objects.According to the occurrence of DCI after aSAH,they were divided into non DCI group (181 patients) and DCI group (79 patients).The clinical data of the two groups were collected,the levels of serum mir-210 were determined by real-time fluorescent quantitative PCR (qRT-PCR),and the levels of HIF-1α in serum were determined by enzyme-linked immunosorbent assay (ELISA).Results There were significant differences in aneurysm location,Hunt-Hess grade and Fisher grade between the two groups (P<0.05).The levels of mir-210 and HIF-1α in DCI group were significantly higher than those in non DCI group (P<0.05).Pearson test showed that there was a positive correlation between serum mir-210 level and HIF-1α level in aSAH patients (P<0.05).Multivariate logistic regression analysis showed that Hunt-Hess grade≥3,Fisher grade≥3 and high levels of serum mir-210 and HIF-1α were independent risk factors for DCI after aSAH (P<0.05).ROC curve analysis showed that the area under the curve of DCI after aSAH predicted by serum mir-210 combined with HIF-1α level was higher than that predicted by the two alone,with the sensitivity of 83.33% and the specificity of 94.44%.Conclusions The levels of mir-210 and HIF-1α in patients with DCI after aSAH are all increased,which can be used as potential indexes to judge the occurrence of DCI after aSAH.
- Full text:2024080211084434794The relationships between the levels of serum mir-210 and HIF-1α and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.pdf
