- VernacularTitle: 非致残性缺血性脑血管事件患者早期进展的危险因素
- Author:
Huijuan WAN
1
;
Weichao JIANG
1
;
Xiongjie ZHUANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Non-disabling ischemic cerebrovascular events; Diabetes mellitus; White matter hyperintensity; Infection
- From: Journal of Apoplexy and Nervous Diseases 2020;37(5):429-434
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the risk factors for early deterioration in neurological function/progressive neurological deficit in patients with non-disabling ischemic cerebrovascular events (NICE). Methods We conducted a retrospective analysis consecutive patient with non-disabling ischemic cerebrovascular events from the Department of Neurology,the First Affiliated Hospital of Xiamen University between January 2016 and December 2019.Patients were divided into progressive group (n=70) and non-progressive group (n=254) and the term progressive were defined as patients had an increase in National Institutes of Health Stroke Scale(NIHSS) score by ≥2 points within 7-day. Patient demographics,clinical and radiological data were recorded and analyzed. Multinomial logistic regression analysis was performed to determine the independent risk factors for early progression in patients with NICE. Results On univariate analysis,the incidence of diabetes mellitus,stenosis or occlusion in the corresponding artery,acute infection and new onset ischemic stroke were significantly higher in progressive group than in non-progressive group (P<0.05).The proportion of higher Fazekas scores (PWMH 2~3,PWMH+DWNH 3~6) in progressive group was significantly higher than that in non-progressive group(P<0.05). Multivariate logistic regression analysis showed that diabetes mellitus (OR=2.355,95%CI 1.220~4.546,P=0.011),stenosis or occlusion in the corresponding artery (OR=2.542,95%CI 1.405~4.600,P=0.002),acute infection(OR=4.513,95%CI 1.699~11.986,P=0.002),new onset ischemic stroke (OR=2.820,95%CI 1.022~7.781,P=0.045),higher Fazekas scores(PWMH+DWNH 3~6,OR=2.061,95%CI 1.119~3.798,P=0.020;PWMH 2~3,OR=2.046,95%CI 1.096~3.817,P=0.024) were independently associated with early progression in patient with NICE. Conclusion Diabetes mellitus,stenosis or occlusion in the corresponding artery,acute infection,new onset ischemic stroke,higher Fazekas scores (PWMH+DWNH 3~ 6,PWMH 2~3) may increase the risk of early progression in patient with NICE.
- Full text:2024080123350277328Risk factors for early progression in patient with non-disabling ischemic cerebrovascular events.pdf