Clinical differential diagnosis points between multiple sclerosis and cerebral small vessels diseases (one case example)
10.19845/j.cnki.zfysjjbzz.2020.0379
- VernacularTitle: 多发性硬化和脑小血管病的临床易误诊点解析（附1例病例分析）
- Author:
Meijuan ZHANG
1
;
Linjie YU
1
;
Hengfeng LU
1
Author Information
1. Department of Neurology，Nanjing Drum Tower Hospital of Nanjing University,Nanjing 21008,China
- Publication Type:Journal Article
- Keywords:
Multiple Sclerosis;
Cerebral small vessel disease;
Differential diagnosis;
Imaging characteristics
- From:
Journal of Apoplexy and Nervous Diseases
2020;37(6):498-501
- CountryChina
- Language:Chinese
-
Abstract:
Objective To dissect the clinical and imaging differences between atypical multiple sclerosis and cerebral small vessels diseases.Methods We presented one case of a hereditary cerebral small vessel disease-autosomal dominant genetic disease combined with subcortical infarction and white matter encephalopathy (CADASIL),which was initially misdiagnosed as multiple sclerosis.Afterwards.We reviewed literature regarding typical images and clinical aspects in multiple sclerosis and cerebral small vessels diseases and discussed the differential diagnosis points.Results Multiple sclerosis often starts in young adults,with IgG index greater than 0.7,positive oligoclonal band,central venous signs,few microbleeding and asymmetric periventricular white matter lesions on MRI scan.On the contrary,cerebral small vessel diseases often start in old patients with vascular risk factors.MRI scan often shows the lacunar cerebral infarction,microbleeding,brain atrophy and symmetric periventricular white matter hyperintensity.Conclusion Understanding the differential points between the two diseases may help avoid misdiagnosis and initiate reasonable treatment immediately.
- Full text:2024080122371183425Clinical differential diagnosis points between multiple sclerosis and cerebral small vessels diseases one case example).pdf
